About
Dr. Christina Ledbetter is a clinical neuroscientist and researcher with a PhD in pharmacology, toxicology, and neuroscience. She specializes in functional Magnetic Resonance Imaging (fMRI) and brain mapping for surgical planning. She is a research fellow in the Department of Neurosurgery at LSU Health Sciences Center in Shreveport, LA where she is the Director of the Clinical Neuroimaging Lab. Her research expertise is applied to neurological conditions including cognitive impairment, Parkinson’s disease, epilepsy, brain tumors, and traumatic brain injury. With a background in both medical imaging and neuroscience, she is an expert at using fMRI to assess changes in the brain following neuroplasticity-based interventions with a particular interest in the Default Mode Network (DMN) and the correlation of changes in network connectivity with changes on neuropsychological testing measures.
ResearchGate Profile: https://www.researchgate.net/profile/Christina-Ledbetter
Publications
Moore, A.L., Miller, T.M., Moore, J.J., Ledbetter, C. (2023). A Real-World Data Study on the Impact of the ReadRx Cognitive Training and Reading Intervention on Cognition, Basic Reading Ability, and Psychosocial Skills for 3527 Children. Psychology Research and Behavior Management,16,1195-1220.
https://doi.org/10.2147/PRBM.S397665
Disbrow, E. A., Glassy, N. D., Dressler, E. M., Russo, K., Franz, E. A., Turner, R. S., Ventura, M. I., Hinkley, L., Zweig, R., Nagarajan, S. S., Ledbetter, C. R., & Sigvardt, K. A. (2022). Cortical oscillatory dysfunction in Parkinson disease during movement activation and inhibition. PloS one, 17(3), e0257711. https://doi.org/10.1371/journal.pone.0257711
Disbrow, E., Stokes, K., Ledbetter, C., & Patterson, J., Kelley, R., Pardue, S., Reekes, T., Larmeu, L., Batra, V., … & Kevil, C. (2021). Plasma hydrogen sulfide: A biomarker of Alzheimer’s disease and related dementias. Alzheimer’s & Dementia. 17. 10.1002/alz.12305. http://dx.doi.org/10.1002/alz.12305
Moore, A.L., Miller, T.M., & Ledbetter, C. (2021). Remote vs. In-Person Delivery of LearningRx One-on-One Cognitive Training During the COVID-19 Pandemic: A Non-inferiority Study. Frontiers in Psychology, 12, 749898.
doi: 10.3389/fpsyg.2021.749898
Moore, A.L., Miller, T.M., & Ledbetter, C. (2021). Reliability Evidence for the Gibson Assessment of Cognitive Skills (GACS): A Brief Tool for Screening Cognitive Skills Across the Lifespan. Psychology Research and Behavior Management, 14, 31-40. https://doi.org/10.2147/PRBM.S291574
Reekes, T., Higginson, C., Ledbetter, C., Sathivadivel, N., Zweig, R., & Disbrow, E. (2020). Sex specific cognitive differences in Parkinson disease. NPJ Parkinson’s Disease. 6. 10.1038/s41531-020-0109-1. http://dx.doi.org/10.1038/s41531-020-0109-1
Moore, A.L., Carpenter, D., James, R., Miller, T., Moore, J., Disbrow, E., & Ledbetter, C. (2020). Neuroimaging and Neuropsychological Outcomes Following Clinician-Delivered Cognitive Training for Six Patients with Mild Brain Injury: A Multiple Case Study. Frontiers in Human Neuroscience, 14(229), 1-15. https://doi.org/10.3389/fnhum.2020.00229
Moore, A., & Ledbetter, C. (2020). Ethical considerations and lessons learned in a randomized controlled trial of ThinkRx cognitive training for children with learning disabilities and/or ADHD. SAGE Research Methods Cases. doi:10.4135/9781529734072 Link to author’s copy
James, R., Moore, A.L., Carpenter, D., Miller, T., & Ledbetter, C. (2019). Feasibility of a Functional Medicine Approach to Slowing Clinical Cognitive Decline in Patients Over Age 55: A Multiple Case Study Report. OBM Integrative and Complementary Medicine, 4(3). doi: 10.21926/obm.icm.1903054 View PDF Link to article
Moore, A.L., & Ledbetter, C. (2019). The Promise of Clinician-Delivered Cognitive Training for Children Diagnosed with ADHD. Journal of Mental Health and Clinical Psychology, 3(3), 3-8. doi: 10.29245/2578-2959/2019/3.1180
Link to article.
Moore, A.L., Carpenter, D.M., Miller, T.M., & Ledbetter, C., (2019). ThinkRx Cognitive Training for Adults over Age 50: Clinician-Caregiver Partners in Delivery as Effective as Clinician-Only Delivery. Psychology and Neuroscience, 12(2), 291-306. doi: 10.1037/pne0000162 Link to author’s copy of the article
Moore, A.L., Carpenter, D.M., Miller, T.M., & Ledbetter, C. (2019). Comparing Two Methods of Delivering ThinkRx Cognitive Training to Children Ages 8-14: A Randomized Controlled Trial of Equivalency. Journal of Cognitive Enhancement, 3(3), 261-270. doi.org/10.1007/s41465-018-0094-z Read the article (Link to results poster)
Morgan, H. E., Ledbetter, C. R., Ferrier, C., Zweig, R. M., & Disbrow, E. A. (2018). Altered Cortico-Limbic Network Connectivity in Parkinsonian Depression: The Effect of Antidepressants. Journal of Parkinson’s disease, 8(3), 429–440. https://doi.org/10.3233/JPD-171204
Holly, K. S., Fitz-Gerald, J. S., Barker, B. J., Murcia, D., Daggett, R., Ledbetter, C., Gonzalez-Toledo, E., & Sun, H. (2018). Differentiation of High-Grade Glioma and Intracranial Metastasis Using Volumetric Diffusion Tensor Imaging Tractography. World neurosurgery, 120, e131–e141. https://doi.org/10.1016/j.wneu.2018.07.230
Moore, A.L., Carpenter, D.M., Ledbetter, C., & Miller, T.M. (2018). Clinician-delivered cognitive training for children with attention problems: Transfer effects on cognitive and behavior from the ThinkRx randomized controlled trial. Neuropsychiatric Disease and Treatment, 14, 1671-1683. doi: 10.2147/NDT.S165418
Read the article Link to video abstract: https://www.youtube.com/watch?v=Tso9xhKRkao
Ledbetter, C., & Moore, A. (2018). Neuroimaging outcomes of a cognitive rehabilitation training program. Journal of Neuroimaging, 28(2), 225-233. doi: 10.1111/jon.12507 Read the article. Or read the abstract on pages 230-231: Neuroimaging Outcomes for TBI and MCI_J of Neuroimaging
Holly, K. S., Barker, B. J., Murcia, D., Bennett, R., Kalakoti, P., Ledbetter, C., Gonzalez-Toledo, E., Nanda, A., & Sun, H. (2017). High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases. Frontiers in surgery, 4, 18. https://doi.org/10.3389/fsurg.2017.00018
Ledbetter, C., Moore, A.L., Mitchell, T. (2017). Cognitive effects of ThinkRx cognitive rehabilitation training for eleven soldiers with brain injury: A retrospective chart review. Frontiers in Psychology, 8(825). doi: 10.3389/fpsyg.2017.00825 http://journal.frontiersin.org/article/10.3389/fpsyg.2017.00825/full
Carpenter, D., Ledbetter, C., & Moore, A.L. (2016). LearningRx cognitive training effects in children ages 8-14: A randomized controlled study. Applied Cognitive Psychology, 30(5), 815-826. doi: 10.1002/acp.3257
http://onlinelibrary.wiley.com/doi/10.1002/acp.3257/full
Sharma, K., Kalakoti, P., Shaughnessy, J. E., De La Cruz, N., Dossani, R. H., Zhu, P., Gonzalez-Toledo, E., Ledbetter, C., Pinskton, J. B., Nanda, A., Riel-Romero, R. M., Minagar, A., Notarianni, C., & Sun, H. (2016). Psammomatous Cavernous Malformation Presenting as Drug-Resistant Epilepsy: Case Illustration and Review of Literature. World neurosurgery, 93, 120–126. https://doi.org/10.1016/j.wneu.2016.05.093